A research published online in The FASEB Journal suggests that sperm of overweight dads may result in obesity and diabetes-like symptoms in just two generations of offspring. They have identified that molecular signals in the sperm of obese fathers can increase the risk of both the children and their grandchildren inheriting obesity, despite the fact that they are eating healthily.
The lead author of this paper, Dr Tod Fullston explained that a daddy’s diet affects the molecular makeup of their sperm. With obese dads, the fluctuations in their sperm – within their own microRNA molecules – may program the embryo for obesity or metabolic disorder later in life. For female offspring, there is a heightened chance of becoming overweight or fat. Moreover, they found that there’s a heightened likelihood of both male and female offspring developing metabolic disorder similar to type 2 diabetes.
The analysis also expanded into the second generation of progeny, which showed indications of similar metabolic disorders, such as obesity, though it was not as intense as the first generation.
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